Rejection as a whole is not a great reason to run out and self-publish. I mean, think about it: “Everyone else hates it, so why not punish readers with it? To the Resentmentmobile!” But — but! — sometimes, the overall pattern of rejection does indicate value in self-publishing. Getting a lot of those “it’s good, but I can’t do anything with it” rejections tells you that the risk-averse industry isn’t willing to, duh, take a risk. So, you can absorb the risk and self-publish.